Complement Component 3 (C3) Haplotypes and Risk of Advanced Age-Related Macular Degeneration
نویسندگان
چکیده
منابع مشابه
Complement component 3 (C3) haplotypes and risk of advanced age-related macular degeneration.
PURPOSE Nonsynonymous coding single nucleotide polymorphisms (nsSNPs) in complement component 3 (C3) alter the risk of age-related macular degeneration (AMD). This was a study of the effect of haplotypes across C3 on AMD risk. METHODS Nine SNPs tagging haplotypes across C3 were genotyped on 738 subjects at the Mayo Clinic. Haplotype analyses were performed with and without conditioning on ind...
متن کاملThe complement component 5 gene and age-related macular degeneration.
OBJECTIVE To investigate the association between variants in the complement component 5 (C5) gene and age-related macular degeneration (AMD). DESIGN Separate and combined data from 3 large AMD case-control studies and a prospective population-based study (The Rotterdam Study). PARTICIPANTS A total of 2599 AMD cases and 3458 ethnically matched controls. METHODS Fifteen single nucleotide po...
متن کاملComplement C3 variant and the risk of age-related macular degeneration.
BACKGROUND Age-related macular degeneration is the most common cause of blindness in Western populations. Susceptibility is influenced by age and by genetic and environmental factors. Complement activation is implicated in the pathogenesis. METHODS We tested for an association between age-related macular degeneration and 13 single-nucleotide polymorphisms (SNPs) spanning the complement genes ...
متن کاملC3 R102G polymorphism increases risk of age-related macular degeneration.
Inflammation has long been suspected to play a role in the pathogenesis of age-related macular degeneration (AMD). Association of variants in the complement factor H (CFH) and complement factor B (CFB) genes has targeted the search for additional loci to the alternative complement cascade, of which C3 is a major component. Two non-synonymous coding polymorphisms within C3, R102G and L314P, have...
متن کاملComplement inhibitors for age-related macular degeneration.
BACKGROUND Given the relatively high prevalence of age-related macular degeneration (AMD) and the increased incidence of AMD as populations age, the results of trials of novel treatments are awaited with much anticipation. The complement cascade describes a series of proteolytic reactions occurring throughout the body that generate proteins with a variety of roles including the initiation and p...
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ژورنال
عنوان ژورنال: Investigative Opthalmology & Visual Science
سال: 2009
ISSN: 1552-5783
DOI: 10.1167/iovs.08-3231